R-universe - csogroup (undefined)

SelectSim - Selected Events Linked by Evolutionary Conditions in Cancer

Implements the 'SelectSim' methodology for identifying patterns of co-occurrence and mutual exclusivity between functional genomic alterations in cancer cohorts. The package processes mutation annotation data, constructs alteration matrices, estimates expected alteration-pair frequencies, and quantifies deviations associated with selective interactions. The methodology is described in Iyer et al. (2026) <doi:10.1038/s41588-026-02661-4>.

Last updated

cancer-genomicsexome-sequencing-analysismutation-analysisopenblascpp

4.90 score 4 stars 8 scripts 291 downloads

consensusTADs - Generate Consensus Topologically Associating Domains from Multiple Prediction Tools

Integrates Topologically Associating Domains (TADs) predictions from multiple computational tools to generate high-confidence consensus TAD sets. The package implements the Measure of Concordance (MoC) metric to quantify agreement between different TAD predictions and uses dynamic programming algorithms to select optimal non-overlapping TAD boundaries. This approach helps resolve inconsistencies between TAD calling methods and produces more reliable chromatin domain annotations for downstream genomic analyses.

Last updated

softwarehic

3.00 score 2 scripts